However, the fact the Magpies' Championship trip to Reading at the weekend was postponed and that they do not play again until promotion rivals West Brom arrive at St James' Park on Monday means Hughton could yet opt to field his biggest names.
Midfielder Alan Smith has recovered from an eye injury suffered during the first game, although the manager will decide over the next 24 hours whether to use him or not.
Only Joey Barton remains on the casualty list after a foot injury and his return, which was scheduled for the final week of this month, may have to be put back by seven days because of his lack of outdoor training in recent days because of the weather.
Plymouth striker Jamie Mackie will miss out.
Mackie, who tops the Argyle scoring charts with five goals along with on-loan Blackburn winger Alan Judge, is suffering with sickness and has not flown north with Paul Mariner's squad.
Mackie was partnered with Kiwi striker Rory Fallon when Argyle drew 0-0 with Newcastle in the first game on Saturday January 2.
Mariner has the option of calling upon Alan Gow, Ashley Barnes or teenager Joe Mason, all strikers and unused substitutes at Home Park.
Central defender Kari Arnason (leg) is an injury doubt while midfielder Jim Patterson is still ruled out by a hamstring injury.
Winger Yala Bolasie has returned from his loan spell at League Two Barnet but is cup-tied.
Sporting Life