Notts County have doubts over goalkeeper Rob Burch and striker Ben Burgess, who could both miss the trip to Home Park.
Burch suffered a toe injury in Saturday's home defeat against Huddersfield Town, while Burgess picked up a knock in the same game.
MATCH FACTS
Head-to-head
• This is the 40th clash between these clubs. Notts County have won 21 and Plymouth 10 of the previous 39, with eight drawn.
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• This is their first meeting in the League Cup.
Plymouth
• Plymouth have gone out in the first round in 15 of the last 17 years, including the last two.
• Argyle, the 1965 and 1974 semi-finalists, need to score once to bring their all-time League Cup goals total to 150.
Notts County
• County, quarter-finalists on three occasions, have failed to make it past the first round in three of the last five years.
Source: BBC Sport
Source: BBC Sport